Creatine? and HD
I get a lot of my info from 'Huntington's disease drug works'. It is a fantastic site. Look under neuroprotection. A direct link to the creatine is http://hddrugworks.org/index.php?option=com_content&task=view&id=160&Itemid=81#creatine I think it advises you need to take 8g at least but it is best to work up to 20g a day (split doses) and take an consumer lab approved one. The clinical trial Creatine is Neotine. I can't afford the shipping to uk, nearly expensive as neotine. I buy Met-Rx Hardcore creatine powder. My mum even takes it!!!
13 months ago
Shaun is on creatine. Met-Rx. 20 mg a day. Also on 300 mg of Co-Q10. Some St. John's Wort for his nerves. I like to believe it is having a positive effects versus just wasting so much money
13 months ago
13 months ago
The article in Neuroscience 2002 mentions about the role of creatine in the treatment of HD.
Health implications of creatine: can oral creatine supplementation protect against neurological and atherosclerotic disease?
Neuroscience. 2002;112(2):243-60.
Creatine supplementation displayed neuroprotective effects in several animal models of neurological disease, such as Huntington's disease, Parkinson's disease, or amyotrophic lateral sclerosis. All these findings pinpoint to a close correlation between the functional capacity of the creatine kinase/phosphorylcreatine/creatine system and proper brain function. They also offer a starting-point for novel means of delaying neurodegenerative disease, and/or for strengthening memory function and intellectual capabilities.
According to Mayo Clinic there is only preliminary evidence that creatine may be well-tolerated and safe in Huntington's disease patients. Further research is needed before a recommendation can be made. Studies have been done by administering 8 gm per day of creatine for 16 weeks.
In a randomized, double-blind, placebo-controlled study in 64 subjects with Huntington disease (HD), 8 g/day of creatine administered for 16 weeks was well tolerated and safe. Serum and brain creatine concentrations increased in the creatine-treated group and returned to baseline after washout. Serum 8-hydroxy-2'-deoxyguanosine (8OH2'dG) levels, an indicator of oxidative injury to DNA, were markedly elevated in HD and reduced by creatine treatment.
(Source - 1. http://www.mayoclinic.com/health/creatine/NS_patient-creatine. 2. Neurology. 2006 Jan 24;66(2):250-2.)
Creatine supplementation in Huntington's disease: a placebo-controlled pilot trial
Neurology. 2003 Oct 14;61(7):925-30
OBJECTIVE:
To evaluate the effect of creatine (Cr) supplementation (5 g/day) in Huntington's disease (HD).
METHODS:
A 1-year double-blind placebo-controlled study was performed in 41 patients with HD (stage I through III). At baseline and after 6 and 12 months, the functional, neuromuscular, and cognitive status of the patients was assessed by a test battery that consisted of 1) the Unified Huntington's Disease Rating Scale (UHDRS), 2) an exercise test on an isokinetic dynamometer to assess strength of the elbow flexor muscles, 3) a maximal exercise test on a bicycle ergometer to evaluate cardiorespiratory fitness, and 4) a test to assess bimanual coordination ability. Following the baseline measurements, the subjects were assigned to either a creatine (n = 26) or a placebo group (n = 15).
RESULTS:
Scores on the functional checklist of the UHDRS (p < 0.05), maximal static torque (p < 0.05), and peak oxygen uptake (p < 0.05) decreased from the start to the end of the study, independent of the treatment received. Cognitive functioning, bimanual coordination ability, and general motor function (total motor scale, UHDRS) did not change from baseline to 1 year in either group.
CONCLUSION:
One year of Cr intake, at a rate that can improve muscle functional capacity in healthy subjects and patients with neuromuscular disease (5 g/day), did not improve functional, neuromuscular, and cognitive status in patients with stage I to III HD.
13 months ago
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Robert Antón